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Image Search Results
Journal: Nature Communications
Article Title: Quantification and prediction of human fetal (-)-Δ 9 -tetrahydrocannabinol/(±)-11-OH-Δ 9 -tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity
doi: 10.1038/s41467-025-55863-5
Figure Lengend Snippet: First, the model was built in Simcyp V22 for the healthy non-pregnant population by optimizing and verifying the Δ 9 -THC elimination and distribution kinetics after intravenous administration. Then, Δ 9 -THC absorption kinetics and 11-OH-THC elimination and distribution kinetics were verified after inhalation and oral Δ 9 -THC consumption. The Δ 9 -THC kinetics in the non-pregnant model were also verified through drug-drug interaction and pharmacogenetic studies. Then, using our in-house m-f-PBPK model, built in MATLAB Simulink R2023a, which includes the placental and fetal compartments as well as gestational age-dependent physiological changes, the umbilical venous plasma (UVP) and fetal tissue concentrations were predicted. Figure was created with BioRender.com.
Article Snippet: The code used for the
Techniques: Clinical Proteomics